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The state of the art in biopharmaceutical FUSION PROTEIN DESIGN

Fusion proteins belong to the most lucrative biotech drugs—with Enbrel® being one of the best-selling biologics worldwide. Enbrel® represents a milestone of modern therapies just as Humulin®, the first therapeutic recombinant protein for human use, approved by the FDA in 1982 and Orthoclone® the first monoclonal antibody reaching the market in 1986. These first generation molecules were soon followed by a plethora of recombinant copies of natural human proteins, and in 1998, the first de novo designed fusion protein was launched.

Fusion Protein Technologies for Biopharmaceuticals examines the state of the art in developing fusion proteins for biopharmaceuticals, shedding light on the immense potential inherent in fusion protein design and functionality. A wide pantheon of international scientists and researchers deliver a comprehensive and complete overview of therapeutic fusion proteins, combining the success stories of marketed drugs with the dynamic preclinical and clinical research into novel drugs designed for as yet unmet medical needs.

The book covers the major types of fusion proteins—receptor-traps, immunotoxins, Fc-fusions and peptibodies—while also detailing the approaches for developing, delivering, and improving the stability of fusion proteins. The main body of the book contains three large sections that address issues key to this specialty: strategies for extending the plasma half life, the design of toxic proteins, and utilizing fusion proteins for ultra specific targeting. The book concludes with novel concepts in this field, including examples of highly relevant multifunctional antibodies.

Detailing the innovative science, commercial realities, and brilliant potential of fusion protein therapeutics, Fusion Protein Technologies for Biopharmaceuticals is a must for pharmaceutical scientists, biochemists, medicinal chemists, molecular biologists, pharmacologists, and genetic engineers interested in determining the shape of innovation in the world of biopharmaceuticals.

• Sales Rank: #3424251 in Books
• Brand: Brand: Wiley
• Published on: 2013-03-18
• Original language: English
• Number of items: 1
• Dimensions: 11.39" h x 1.40" w x 8.80" l, 3.85 pounds
• Binding: Hardcover
• 680 pages

Features

• Used Book in Good Condition

Review

“Overall, this book is a “bona fide” companion for newcomers, as well as for experts in the pharmaceutical industry, in biotechnology or universities with affiliations to industry and medicine.”  (mAbs, 15 April 2015)

About the Author

STEFAN R. SCHMIDT, PhD, is Vice President for Downstream Processing at Rentschler Biotechnology. Previously, he served as CSO at ERA Biotech and Associate Director for Protein Science at AstraZeneca. Dr. Schmidt has chaired many international conferences and written several original articles, reviews, and book chapters.

Most helpful customer reviews

0 of 0 people found the following review helpful.
Five Stars
By John Semiklose
Great product.. Just as advertised! Thank you!!!!!!

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[S476.Ebook] Free Ebook Wired: The Short Life and Fast Times of John Belushi, by Bob Woodward

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Wired: The Short Life and Fast Times of John Belushi

• Sales Rank: #455871 in Books
• Brand: Simon & Schuster
• Published on: 1985-11
• Original language: English
• Number of items: 1
• Binding: Hardcover
• 461 pages

Features

• Great product!

Most helpful customer reviews

7 of 7 people found the following review helpful.
Decent chronology of Johns life; focus on his dark last days
By A Customer
Woodward's book is, of course, flawed like Judy Belushi's "Samurai Widow"; but other than these two books there is nothing more of Belushi to refer back to, in the written form. There will always be the SNL videos, the Blues Brothers CDs, or the handful of movies John did, but where does one interested enough start from when they want to make some chronological order of Belushi's life; to learn more about his exhuberent ascent, his tumultuous descent and his final dark months, weeks and days? Bob Woodward gives the reader a dry and thorough, if not somewhat-slanted, take on John Belushi's 33 years on planet Earth. The reader simply cannot help but get the feeling that the author is emphasizing the downward spiral and the end of a manically funny man, which is why this book wasn't received very well when it was first released, back in 1984.. Still, from JB's days in Wheaton, Illinois, Second City Chicago and National Lampoon, to Saturday Night Live, Hollywood and the Chateau Maramont Bungalow #3, Woodward's book is worth 3 1/2 starts and, at the very least, one good read-through.

15 of 18 people found the following review helpful.
Puts things in perspective
By Mark Coffey
I read this book about once a year to remind myself of how much I want to live. For anyone caught up in the illusion of the glory of life in the fast lane, the second half of this book, dealing with Belushi's last great binge in minute-by-minute detail, should be a real eye-opener. Woodward paints a balanced portrait of a much-loved, charasmatic individual trapped by his own demons. Alternately fascinating and horrifying, this is perhaps the best celebrity biography I have read. I sincerely hope it comes back into print - if not, I suggest you try to hunt a copy down; it is worth your time.

12 of 15 people found the following review helpful.
Very interesting and sad book, but not very well written.
By Clockwork Apple
The story of John Belushi's life was a rollercoaster ride of very low times of self destruction, separated by short rises of happiness and accomplishment. John seemed to be someone that just could not be happy in his own skin, he did not see himself as a worthy human being who deserved to be happy, but instead someone who did not deserve his fame, or did not feel he was respected in the ways he thought he should be, he was constantly trying to prove himself. John was selfish, yes, he would binge for weeks on drugs, parties, and the fast life looking to fill that void regardless of who it hurt. He destroyed friendships as fast as he made them, but was always the one quick to apologize and try to mend the bridge he had just burned. I feel sorry for John and wish that he would of been given the help he was crying out to receive. Like so many before and after him his problems were ignored in hopes that he would somehow see the light and snap out of it on his own. John is to blame for his own death, and partial blame goes to his friends, but a huge part of the blame rests on Hollywood's shoulders. A town that rewards it successful entertainers with money and fame, and then quickly shuns them the minute that entertainers value has been sucked dry. Hollywood glorifies a lifestyle, in it's movies, that in reality is an impossible one to maintain. The book is very poorly written in my opinion, and Woodward easily confuses the reader by jumping from quote to quote. The readers many times is left unsure of who the quote is being taken from or who exactly the quote is about. There are a lot of scattered bits of information in the book as well and also many typos. For example in one section John's heart is described as being 222 lbs after his death. The book was interesting but so scattered I found my self struggling to stay focused and had to re-read many paragraphs to fully understand what exactly Woodward was trying to say.

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[J524.Ebook] Free PDF Funk Bass Fills: For Funk R&B Soul & Hip-Hop Berklee Bk/CD, by Anthony Vitti

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(Berklee Guide). This book by Berklee bass prof Anthony Vitti will help you make your bass lines more creative, unique and memorable. Tap into the groove and evolve your bass lines by using fills. This book brings you beyond the basics and helps you incorporate figures into your lines that are natural to the groove, and applicable to many styles. The play-along recordings let you hear the fills in context, then practice them with a rhythm section.

• Sales Rank: #787522 in Books
• Brand: Brand: Berklee Press
• Published on: 2012-05-01
• Original language: English
• Number of items: 1
• Dimensions: 12.00" h x .24" w x 9.00" l, .70 pounds
• Binding: Paperback
• 80 pages

Features

• Brand Name: Baker and Taylor Mfg#: 9780876391303
• Shipping Weight: 0.70 lbs
• Manufacturer:
• Genre:
• All music products are properly licensed and guaranteed authentic.

Most helpful customer reviews

2 of 2 people found the following review helpful.
Some good exercises but a lot of "fillers" rather than really useful fils.
By ToroBoy9
This a very good book for teachers to use as the examples make good practice exercises.
Unfortunately there's not a lot of great fills and many of the exercises seem a bit out of context.
Better as a sight reading skill builder in my opinion.

0 of 1 people found the following review helpful.
Funk Master Vitti Does it Again
By Dusty Redford
This book is filled with material for the serious bassist. The latest book from the professor of Berklee College of Music does not disappoint. It comes with a CD with about 100 tracks on it, so you can hear what is expected from you as you read it. A must buy for any bass player - it covers exactly what he teaches, Funk, R&B, Soul and Hip-Hop. Write another book Mr. Vitti, we need a follow up to this one!

0 of 0 people found the following review helpful.
Useful to some extent
By Dfunkymonkey
This book has some good foundational instruction. Easy enough for beginners/intermediate players. Good variety of fills, grooves and exercises. Most examples are movable across the fretboard. Any improvement in my playing is worth the investment.

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